Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.
Identifieur interne : 000533 ( Main/Exploration ); précédent : 000532; suivant : 000534Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice.
Auteurs : Mitchell R. Dyer [États-Unis] ; Wyeth Alexander [États-Unis] ; Adnan Hassoune [États-Unis] ; Qiwei Chen [États-Unis] ; Tomasz Brzoska [États-Unis] ; Jurgis Alvikas [États-Unis] ; Yingjie Liu [États-Unis] ; Shannon Haldeman [États-Unis] ; Will Plautz [États-Unis] ; Patricia Loughran [États-Unis] ; Hui Li [États-Unis] ; Brian Boone [États-Unis] ; Yoel Sadovsky [États-Unis] ; Prithu Sundd [États-Unis] ; Brian S. Zuckerbraun [États-Unis] ; Matthew D. Neal [États-Unis]Source :
- Journal of thrombosis and haemostasis : JTH [ 1538-7836 ] ; 2019.
Abstract
Traumatic injury can lead to dysregulation of the normal clotting system, resulting in hemorrhagic and thrombotic complications. Platelet activation is robust following traumatic injury and one process of platelet activation is to release of extracellular vesicles (PEV) that carry heterogenous cargo loads and surface ligands.
DOI: 10.1111/jth.14563
PubMed: 31294514
Affiliations:
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Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Liu, Yingjie" sort="Liu, Yingjie" uniqKey="Liu Y" first="Yingjie" last="Liu">Yingjie Liu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Haldeman, Shannon" sort="Haldeman, Shannon" uniqKey="Haldeman S" first="Shannon" last="Haldeman">Shannon Haldeman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Plautz, Will" sort="Plautz, Will" uniqKey="Plautz W" first="Will" last="Plautz">Will Plautz</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Loughran, Patricia" sort="Loughran, Patricia" uniqKey="Loughran P" first="Patricia" last="Loughran">Patricia Loughran</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Boone, Brian" sort="Boone, Brian" uniqKey="Boone B" first="Brian" last="Boone">Brian Boone</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Sadovsky, Yoel" sort="Sadovsky, Yoel" uniqKey="Sadovsky Y" first="Yoel" last="Sadovsky">Yoel Sadovsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Obstetrics, Gynecology, and Reproductive Science, Magee-Women's Research Institute, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Sundd, Prithu" sort="Sundd, Prithu" uniqKey="Sundd P" first="Prithu" last="Sundd">Prithu Sundd</name><affiliation wicri:level="2"><nlm:affiliation>Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Zuckerbraun, Brian S" sort="Zuckerbraun, Brian S" uniqKey="Zuckerbraun B" first="Brian S" last="Zuckerbraun">Brian S. Zuckerbraun</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Neal, Matthew D" sort="Neal, Matthew D" uniqKey="Neal M" first="Matthew D" last="Neal">Matthew D. Neal</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of thrombosis and haemostasis : JTH</title><idno type="eISSN">1538-7836</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Traumatic injury can lead to dysregulation of the normal clotting system, resulting in hemorrhagic and thrombotic complications. Platelet activation is robust following traumatic injury and one process of platelet activation is to release of extracellular vesicles (PEV) that carry heterogenous cargo loads and surface ligands.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Dyer, Mitchell R" sort="Dyer, Mitchell R" uniqKey="Dyer M" first="Mitchell R" last="Dyer">Mitchell R. Dyer</name></region><name sortKey="Alexander, Wyeth" sort="Alexander, Wyeth" uniqKey="Alexander W" first="Wyeth" last="Alexander">Wyeth Alexander</name><name sortKey="Alvikas, Jurgis" sort="Alvikas, Jurgis" uniqKey="Alvikas J" first="Jurgis" last="Alvikas">Jurgis Alvikas</name><name sortKey="Boone, Brian" sort="Boone, Brian" uniqKey="Boone B" first="Brian" last="Boone">Brian Boone</name><name sortKey="Brzoska, Tomasz" sort="Brzoska, Tomasz" uniqKey="Brzoska T" first="Tomasz" last="Brzoska">Tomasz Brzoska</name><name sortKey="Chen, Qiwei" sort="Chen, Qiwei" uniqKey="Chen Q" first="Qiwei" last="Chen">Qiwei Chen</name><name sortKey="Haldeman, Shannon" sort="Haldeman, Shannon" uniqKey="Haldeman S" first="Shannon" last="Haldeman">Shannon Haldeman</name><name sortKey="Hassoune, Adnan" sort="Hassoune, Adnan" uniqKey="Hassoune A" first="Adnan" last="Hassoune">Adnan Hassoune</name><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><name sortKey="Liu, Yingjie" sort="Liu, Yingjie" uniqKey="Liu Y" first="Yingjie" last="Liu">Yingjie Liu</name><name sortKey="Loughran, Patricia" sort="Loughran, Patricia" uniqKey="Loughran P" first="Patricia" last="Loughran">Patricia Loughran</name><name sortKey="Neal, Matthew D" sort="Neal, Matthew D" uniqKey="Neal M" first="Matthew D" last="Neal">Matthew D. Neal</name><name sortKey="Plautz, Will" sort="Plautz, Will" uniqKey="Plautz W" first="Will" last="Plautz">Will Plautz</name><name sortKey="Sadovsky, Yoel" sort="Sadovsky, Yoel" uniqKey="Sadovsky Y" first="Yoel" last="Sadovsky">Yoel Sadovsky</name><name sortKey="Sundd, Prithu" sort="Sundd, Prithu" uniqKey="Sundd P" first="Prithu" last="Sundd">Prithu Sundd</name><name sortKey="Zuckerbraun, Brian S" sort="Zuckerbraun, Brian S" uniqKey="Zuckerbraun B" first="Brian S" last="Zuckerbraun">Brian S. Zuckerbraun</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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